Toward a comprehensive neurobiology of IGF‐I

@article{TorresAleman2010TowardAC,
  title={Toward a comprehensive neurobiology of IGF‐I},
  author={Ignacio Torres-Aleman},
  journal={Developmental Neurobiology},
  year={2010},
  volume={70}
}
Insulin‐like growth factor I (IGF‐I) belongs to an ancient family of hormones already present in early invertebrates. The insulin family is well characterized in mammals, although new members have been described recently. Since its characterization over 50 years ago, IGF‐I has been considered a peptide mostly involved in the control of body growth and tissue remodeling. Currently, its most prominent recognized role is as a quasi‐universal cytoprotectant. This role connects IGF‐I with regulation… 
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References

SHOWING 1-10 OF 119 REFERENCES
Insulin and insulin-like growth factor I signalling in neurons.
TLDR
Mounting evidence suggests a complementary role of insulin and IGF-I in the brain, unveiling the cellular and molecular pathways involved in brain insulin/IGF-I actions is helping to establish potentially new therapeutic targets and its exploitation may lead to new treatments for a wide array of brain diseases.
The role of the insulin-like growth factors in the central nervous system
TLDR
In vitro IGF-I has been shown to stimulate the proliferation of neuron progenitors and/or the survival of neurons and oligodendrocytes, and in some cultured neurons, to stimulate function and in vivo studies indicate that IGF- I can influence the development of most, if not all, brain regions.
Circulating insulin-like growth factor I and cognitive function: Neuromodulation throughout the lifespan
The role of circulating IGF-I
TLDR
This review will revisit the IGF system with particular attention to the role of circulating IGF-I in growth regulation, metabolism, and cancer.
The insulin‐like growth factor I system in the rat cerebellum: Developmental regulation and role in neuronal survival and differentiation
TLDR
Analysis of cerebellar cultures by combined in vitro autoradiography and immunocytochemistry with cell‐specific markers indicated that both Purkinje cells (calbindin‐ positive) and other neurons (neurofilament‐positive) contain IGF‐I binding sites.
Role of insulin-like growth factor I signaling in neurodegenerative diseases
TLDR
It is hypothesized that in the majority of neurodegenerative diseases compromised IGF-I support to neurons emerges as part of the pathological cascade during the degenerative process and contributes to neuronal demise.
Regulation of muscle mass by growth hormone and IGF‐I
  • C. Velloso
  • Biology, Medicine
    British journal of pharmacology
  • 2008
TLDR
There is currently very little evidence to support an anabolic role for supraphysiological levels of systemic GH or IGF‐I in skeletal muscle of healthy individuals, and the hypertrophic effects of muscle‐specific IGF-I infusion are well documented in animal models and muscle cell culture systems.
Serum growth factors and neuroprotective surveillance
TLDR
New evidence strongly suggests that IGF-I, and other blood-borne neurotrophic factors such as Fibroblast Growth Factor (FGF-2) or the neurotrophins, exert a tonic trophic input on brain cells, providing a mechanism for what is referred to as neuroprotective surveillance.
Insulin-like growth factors as mediators of functional plasticity in the adult brain.
  • I. Torres-Aleman
  • Biology
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 1999
TLDR
Evidence indicates a role for IGFs in brain plasticity processes by regulating synapse formation, neurotransmitter release and neuronal excitability, and IGFs provide constant trophic support to target cells in the brain and in this way maintain appropriate neuronal function.
...
1
2
3
4
5
...