Toward a comprehensive and systematic methylome signature in colorectal cancers.

  title={Toward a comprehensive and systematic methylome signature in colorectal cancers.},
  author={Hassan Ashktorab and Hamed Rahi and Daniel L Wansley and S. Sunil Varma and Babak Shokrani and Edward Lee and Mohammad R Daremipouran and Adeyinka O Laiyemo and Ajay Goel and John M. Carethers and Hassan Brim},
  volume={8 8},
CpG Island Methylator Phenotype (CIMP) is one of the underlying mechanisms in colorectal cancer (CRC). This study aimed to define a methylome signature in CRC through a methylation microarray analysis and a compilation of promising CIMP markers from the literature. Illumina HumanMethylation27 (IHM27) array data was generated and analyzed based on statistical differences in methylation data (1st approach) or based on overall differences in methylation percentages using lower 95% CI (2nd approach… CONTINUE READING
Highly Cited
This paper has 691 citations. REVIEW CITATIONS
20 Citations
53 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 20 extracted citations

692 Citations

Citations per Year
Semantic Scholar estimates that this publication has 692 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 53 references

Genomic and epigenomic integration identifies a prognostic signature in colon cancer

  • JM Yi, M Dhir, L Van Neste, SR Downing, J Jeschke, SC Glöckner
  • Clin Cancer Res
  • 2011

Similar Papers

Loading similar papers…