Toward a comprehensive and systematic methylome signature in colorectal cancers.

@article{Ashktorab2013TowardAC,
  title={Toward a comprehensive and systematic methylome signature in colorectal cancers.},
  author={Hassan Ashktorab and Hamed Rahi and Daniel L Wansley and S. Sunil Varma and Babak Shokrani and Edward Lee and Mohammad R Daremipouran and Adeyinka O Laiyemo and Ajay Goel and John M. Carethers and Hassan Brim},
  journal={Epigenetics},
  year={2013},
  volume={8 8},
  pages={807-15}
}
CpG Island Methylator Phenotype (CIMP) is one of the underlying mechanisms in colorectal cancer (CRC). This study aimed to define a methylome signature in CRC through a methylation microarray analysis and a compilation of promising CIMP markers from the literature. Illumina HumanMethylation27 (IHM27) array data was generated and analyzed based on statistical differences in methylation data (1st approach) or based on overall differences in methylation percentages using lower 95% CI (2nd approach… CONTINUE READING
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