Toward a Topological Model of the NCX1 Exchanger

@article{Nicoll2002TowardAT,
  title={Toward a Topological Model of the NCX1 Exchanger},
  author={D. Nicoll and M. Ottolia and K. Philipson},
  journal={Annals of the New York Academy of Sciences},
  year={2002},
  volume={976}
}
Abstract: The Na+/Ca2+ exchanger (NCX1) catalyzes the counter‐transport of sodium and calcium ions. Understanding how this is accomplished requires knowledge of the structure of NCX1 and identifying amino acid residues involved in binding and transport of ions. The amino acid sequence of NCX1 has been known for more than a decade. Based on hydropathy analysis, NCX1 was modeled to contain 12 transmembrane segments. In this model, the α‐repeat regions, which are the result of a gene duplication… Expand
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