Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574

@article{ZangerlPlessl2020TowardAS,
  title={Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574},
  author={Eva-Maria Zangerl-Plessl and M. Berger and M. Drescher and Y. Chen and W. Wu and N. Maulide and M. Sanguinetti and A. Stary-Weinzinger},
  journal={Journal of chemical information and modeling},
  year={2020}
}
Outward current conducted by human ether-à-go-go-related gene type 1 (hERG1) K+ channels is important for action potential repolarization in the human ventricle. Rapid, voltage-dependent inactivation greatly reduces outward currents conducted by hERG1 channels and involves conformational changes in the ion selectivity filter (SF). Recently, compounds have been found that activate hERG1 channel function by modulating gating mechanisms such as reducing inactivation. Such activating compounds… Expand
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