Toward a Semisynthetic Stress Response System To Engineer Microbial Solvent Tolerance

@inproceedings{Zingaro2012TowardAS,
  title={Toward a Semisynthetic Stress Response System To Engineer Microbial Solvent Tolerance},
  author={Kyle A. Zingaro and Eleftherios T. Papoutsakis},
  booktitle={mBio},
  year={2012}
}
UNLABELLED Strain tolerance to toxic metabolites is an important trait for many biotechnological applications, such as the production of solvents as biofuels or commodity chemicals. Engineering a complex cellular phenotype, such as solvent tolerance, requires the coordinated and tuned expression of several genes. Using combinations of heat shock proteins (HSPs), we engineered a semisynthetic stress response system in Escherichia coli capable of tolerating high levels of toxic solvents… CONTINUE READING
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