Toward Understanding the Catalytic Mechanism of Human Paraoxonase 1: Site-Specific Mutagenesis at Position 192

@article{Aggarwal2016TowardUT,
  title={Toward Understanding the Catalytic Mechanism of Human Paraoxonase 1: Site-Specific Mutagenesis at Position 192},
  author={Geetika Aggarwal and Rameshwar Prajapati and R. K. Tripathy and Priya Bajaj and A. Iyengar and A. Sangamwar and A. Pande},
  journal={PLoS ONE},
  year={2016},
  volume={11}
}
Human paraoxonase 1 (h-PON1) is a serum enzyme that can hydrolyze a variety of substrates. The enzyme exhibits anti-inflammatory, anti-oxidative, anti-atherogenic, anti-diabetic, anti-microbial and organophosphate-hydrolyzing activities. Thus, h-PON1 is a strong candidate for the development of therapeutic intervention against a variety conditions in human. However, the crystal structure of h-PON1 is not solved and the molecular details of how the enzyme hydrolyzes different substrates are not… Expand
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