Toward Personalized Medicine: Using Cardiomyocytes Differentiated From Urine-Derived Pluripotent Stem Cells to Recapitulate Electrophysiological Characteristics of Type 2 Long QT Syndrome

@inproceedings{Jouni2015TowardPM,
  title={Toward Personalized Medicine: Using Cardiomyocytes Differentiated From Urine-Derived Pluripotent Stem Cells to Recapitulate Electrophysiological Characteristics of Type 2 Long QT Syndrome},
  author={Mariam Jouni and K Si-Tayeb and Zeineb Es-Salah-Lamoureux and X{\'e}nia Latypova and Benoite Champon and Amandine Caillaud and Anais Rungoat and F. Charpentier and Gildas Loussouarn and Isabelle Bar{\'o} and Kazem Zibara and Patricia Lemarchand and Nathalie Gaborit},
  booktitle={Journal of the American Heart Association},
  year={2015}
}
BACKGROUND Human genetically inherited cardiac diseases have been studied mainly in heterologous systems or animal models, independent of patients' genetic backgrounds. Because sources of human cardiomyocytes (CMs) are extremely limited, the use of urine samples to generate induced pluripotent stem cell-derived CMs would be a noninvasive method to identify cardiac dysfunctions that lead to pathologies within patients' specific genetic backgrounds. The objective was to validate the use of CMs… CONTINUE READING

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