Toward Metabolic Phenomics: Analysis of Genomic Data Using Flux Balances

  title={Toward Metabolic Phenomics: Analysis of Genomic Data Using Flux Balances},
  author={Christopher H. Schilling and Jeremy S. Edwards and Bernhard O. Palsson},
  journal={Biotechnology Progress},
Small genome sequencing and annotations are leading to the definition of metabolic genotypes in an increasing number of organisms. Proteomics is beginning to give insights into the use of the metabolic genotype under given growth conditions. These data sets give the basis for systemically studying the genotype−phenotype relationship. Methods of systems science need to be employed to analyze, interpret, and predict this complex relationship. These endeavors will lead to the development of a new… 

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