Tourette's syndrome

@article{Leckman2002TourettesS,
  title={Tourette's syndrome},
  author={James Frederick Leckman},
  journal={The Lancet},
  year={2002},
  volume={360},
  pages={1577-1586}
}
  • J. Leckman
  • Published 16 November 2002
  • Medicine, Psychology
  • The Lancet
Tourette's syndrome: old syndrome, new insights and new treatment.
  • R. Bhidayasiri
  • Psychology, Medicine
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet
  • 2005
TLDR
Tourette's syndrome research has widened its pharmacotherapy to include alpha2-adrenergic agonists and atypical neuroleptics as well as behavioral modification, adjustments, and different surgical approaches.
An Unusual Case of Pure Germinoma in a Patient With Tourette's Syndrome
TLDR
The theory that alterations in the production and regulation of endogenous hormones produced by the midbrain, pineal gland, and periaqueductal grey matter may be linked to the phenotype of Tourette’s syndrome is illustrated.
Tourette’s syndrome in children
TLDR
A review of the Tourette’s syndrome in children, focusing on treatment options, including a drug-by-drug evaluation of available pharmacologic agents and other treatments, is provided.
Neurosurgical strategies for Gilles de la Tourette’s syndrome
TLDR
The rationale for the surgical management of TS is discussed, neurosurgical experiences since the 1960s are reviewed, and the necessity for neuros surgical strategies to be performed with appropriate ethical considerations is highlighted.
Tourette's Syndrome and Pharmacotherapy
TLDR
The current understanding of the phenomenology, epidemiology, pathophysiology, neurochemical and neuroanatomical factors are reviewed, as well as the influence that comorbidities, genetic, environmental, and immunological factors may have on the clinical course of TS.
Tics and Tourette Syndrome.
TLDR
The purpose of this article is to present current information on the phenomenology, epidemiology, comorbidities, and pathophysiology of tic disorders and discuss therapy options to provide clinicians with the necessary information to deliver thoughtful and optimal care to affected individuals.
Addressing the Complexity of Tourette's Syndrome through the Use of Animal Models
TLDR
The different rationales used to develop the respective animal models are critically reviewed, to discuss the potential of the contribution of animal models to elucidate TS disease mechanisms.
Tourette syndrome and tic disorders: a decade of progress.
TLDR
Prospective longitudinal studies and randomized clinical trials have led to the refinement of several models of pathogenesis and advanced the evidence base regarding treatment options, however, fully explanatory models are needed that would allow for more accurate prognosis and the development of targeted and efficacious treatments.
Basal ganglia dysfunction in Tourette's syndrome: a new hypothesis.
  • J. Mink
  • Psychology, Medicine
    Pediatric neurology
  • 2001
The neurosurgical treatment of Tourette's syndrome
TLDR
Because of the serious morbidity, neurosurgery as a treatment option in TS was generally abandoned by most specialized TS centers, but due to the refinement of the stereotactic technique and the safe procedure of deep brain stimulation in other movement disorders, such as Parkinson's disease, tremors and dystonia, neurosurgical treatment has received renewed attention.
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References

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Pathogenesis of Tourette's syndrome.
TLDR
The prospects for advances in interdisciplinary research and therapeutics using this models of disease pathogenesis in the context of CNS development using this model as a guide are closed.
Tourette's syndrome and ‘PANDAS’ Will the relation bear out?
TLDR
Research results supporting the concept of PANDAS are reviewed and it is discussed whether there is a true etiologic relation between streptococcal infection and the onset or exacerbation of childhood neuropsychiatric disorders and whether the use of immune-modifying therapies for these conditions is rational.
Tourette syndrome, associated conditions and the complexities of treatment.
  • M. Robertson
  • Psychology, Medicine
    Brain : a journal of neurology
  • 2000
TLDR
It is suggested that TS is heterogeneous from a variety of standpoints including clinical presentation and psychopathology, and thus neuropharmacological responses and possibly even aetiological and genetic mechanisms are possible.
Basal ganglia dysfunction in Tourette's syndrome: a new hypothesis.
  • J. Mink
  • Psychology, Medicine
    Pediatric neurology
  • 2001
Perinatal factors in the expression of Tourette's syndrome: an exploratory study.
TLDR
Severity of maternal life stress during pregnancy, gender of the child, and severe nausea and/or vomiting during the first trimester were found to be significantly associated with current tic severity.
Exacerbation of Gilles de la Tourette's syndrome associated with thermal stress
TLDR
A family of a TS proband that has several members with obsessive-compulsive symptoms, a bleeding disorder, and an unusual sensitivity to heat is presented.
Case study: a new infection-triggered, autoimmune subtype of pediatric OCD and Tourette's syndrome.
TLDR
The hypothesis is that infections with group A beta-hemolytic streptococci, among others, may trigger autoimmune responses that cause or exacerbate some cases of childhood-onset obsessive-compulsive disorder (OCD) or tic disorders (including Tourette's syndrome).
Tics in Tourette Syndrome: New Treatment Options
  • Y. Awaad
  • Medicine, Psychology
    Journal of child neurology
  • 1999
TLDR
Baclofen/botolinum toxin type A are very effective, safe, and reliable in the treatment of tics/Tourette's syndrome and it is worthwhile considering this treatment approach in patients with tics in order to reduce or avoid the side effects of other medications.
Tourette’s syndrome: a cross sectional study to examine the PANDAS hypothesis
TLDR
The results support a role of group A streptococcal infection and basal ganglia autoimmunity in a subgroup of patients with Tourette’s syndrome and suggest a pathogenic similarity between Sydenham's chorea and some patients with tourette's syndrome.
Current Status of Genetic Studies of Gilles de la Tourette Syndrome
  • C. Barr, P. Sandor
  • Medicine, Biology
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 1998
TLDR
The evidence for the genetic basis of TS and the current status of genetic studies is reviewed and several factors may complicate the search for genes for this disorder.
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