Tourette's syndrome: from behaviour to biology

@article{Singer2005TourettesSF,
  title={Tourette's syndrome: from behaviour to biology},
  author={Harvey S. Singer},
  journal={The Lancet Neurology},
  year={2005},
  volume={4},
  pages={149-159}
}
  • H. Singer
  • Published 2005
  • Medicine, Psychology
  • The Lancet Neurology
Tourette's syndrome (TS) is a chronic neuropsychiatric disorder characterised by motor and vocal tics. Diagnosis is based solely on clinical criteria. The prevalence of this syndrome is estimated to be between one and ten per 1000 children and adolescents and the outcome is generally favourable; most patients improve by their late teens or early adulthood. Affected individuals are at increased risk of various comorbid neurobehavioural problems, the negative effects of which commonly exceed… Expand

Paper Mentions

Interventional Clinical Trial
The main objective of this project is to evaluate the efficacy of subthalamic nucleus deep brain stimulation (STN DBS) in treating motor and phonic tics in medically refractory… Expand
ConditionsGilles de la Tourette Syndrome, Tourette Disorder, Tourette's Syndrome, (+1 more)
InterventionProcedure
Tourette’s Syndrome and Role of Tetrabenazine
TLDR
Results of a retrospective chart review showed that 2 years’ treatment with tetrabenazine resulted in an improvement in functioning and TS-related symptoms in over 80% of patients, findings that suggest that treatment with ritussenazine may have long-term benefits, and suggest that tetrABenazine may be suitable as add-on therapy in patients for whom additional suppression of tics is required. Expand
The genetics of Tourette syndrome
TLDR
An overview of the genetics of Tourette syndrome is provided and how this knowledge has improved understanding of the possible pathogenic mechanisms of this neurological disorder is highlighted. Expand
Tic disorders: from pathophysiology to treatment
TLDR
The management of Tourette Syndrome is often complicated by the presence of attention–deficit/hyperactivity disorder, obsessivecompulsive disorder, and other behaviour disorders, and a multimodal treatment is usually indicated. Expand
A Review and Update on Tourette Syndrome: Where Is the Field Headed?
TLDR
The complexities of TS and the challenges in understanding its pathophysiology and in selecting the most appropriate treatment are discussed and an expert’s view of where the field of TS may be headed is offered. Expand
Putting the Pieces Together in Gilles de la Tourette Syndrome: Exploring the Link Between Clinical Observations and the Biological Basis of Dysfunction
TLDR
This review reports data and discoveries of scientific and clinical relevance from a wide variety of methods and provides up-to-date information about the current understanding of the pathomechanisms underlying Tourette syndrome and gives a comprehensive overview of the current state of knowledge. Expand
The Gilles De La Tourette syndrome: the current status
  • M. Robertson
  • Medicine
  • Archives of Disease in Childhood: Education & Practice Edition
  • 2012
TLDR
Intriguing neuroanatomical and brain circuitry abnormalities have now been suggested in GTS; the most evidence is for cortical thinning and a reduction in the size of the caudate nucleus. Expand
Tourette Syndrome: Bridging the Gap between Genetics and Biology
TLDR
The findings that are emerging from genetic studies will allow researchers to piece together the underlying components of the disease in the hopes that a deeper understanding of Tourette syndrome can lead to improved treatments for those affected by it. Expand
56 – Circuits to Synapses: The Pathophysiology of Tourette Syndrome
Tourette syndrome (TS) is a childhood-onset neuropsychiatrical disorder characterized by chronic motor and vocal tics that are frequently accompanied by coexisting problems such asExpand
An introduction to the clinical phenomenology of Tourette syndrome.
TLDR
The complexity of the Tourette spectrum has been confirmed by cluster and factor analytical approaches, and is likely to inform the study of the genetic basis of this disorder, as well as future reappraisal of its nosography, with the development of novel clinical subtypes. Expand
Attention deficit hyperactivity disorder, tics and Tourette’s syndrome: the relationship and treatment implications. A commentary
  • M. Robertson
  • Psychology, Medicine
  • European child & adolescent psychiatry
  • 2006
TLDR
The comorbidity between TS and ADHD is discussed and treatment suggestions are offered, including atomoxetine, which although not documented widely in the setting of tics and TS, may prove useful in this setting; further research is required. Expand
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