Tourette's syndrome: [I-123]beta-CIT SPECT correlates of vocal tic severity.

  title={Tourette's syndrome: [I-123]beta-CIT SPECT correlates of vocal tic severity.},
  author={Adrienne J Heinz and Michael B. Knable and Steve S Wolf and Douglas W. Jones and Julia G Gorey and Thomas Michael Hyde and Daniel R. Weinberger},
  volume={51 4},
OBJECTIVE To examine in vivo the density of brain monoaminergic transporters in Tourette's syndrome (TS). BACKGROUND TS is a heritable neuropsychiatric disorder characterized by chronic vocal and motor tics and is often associated with obsessive-compulsive symptoms. Hyperstimulation of dopamine receptors and dysfunction of serotonergic transmission have been implicated in its pathogenesis, but direct evidence of involvement of these neurochemical systems has been limited. METHODS Symptom… CONTINUE READING


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