Touch responsiveness in zebrafish requires voltage-gated calcium channel 2.1b.

@article{Low2012TouchRI,
  title={Touch responsiveness in zebrafish requires voltage-gated calcium channel 2.1b.},
  author={Sean Eric Low and Ian G. Woods and Mathieu Lachance and Joel Ryan and Alexander F Schier and Louis Saint-Amant},
  journal={Journal of neurophysiology},
  year={2012},
  volume={108 1},
  pages={148-59}
}
The molecular and physiological basis of the touch-unresponsive zebrafish mutant fakir has remained elusive. Here we report that the fakir phenotype is caused by a missense mutation in the gene encoding voltage-gated calcium channel 2.1b (CACNA1Ab). Injection of RNA encoding wild-type CaV2.1 restores touch responsiveness in fakir mutants, whereas knockdown of CACNA1Ab via morpholino oligonucleotides recapitulates the fakir mutant phenotype. Fakir mutants display normal current-evoked synaptic… CONTINUE READING
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