Touch, act and go: landing and operating on nucleosomes.

  title={Touch, act and go: landing and operating on nucleosomes.},
  author={Valentina Speranzini and Simona Pilotto and Titia Sixma and Andrea Mattevi},
  journal={The EMBO journal},
  volume={35 4},
Chromatin-associated enzymes are responsible for the installation, removal and reading of precise post-translation modifications on DNA and histone proteins. They are specifically recruited to the target gene by associated factors, and as a result of their activity, they contribute in modulating cell identity and differentiation. Structural and biophysical approaches are broadening our knowledge on these processes, demonstrating that DNA, histone tails and histone surfaces can each function as… CONTINUE READING
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