Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.

  title={Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.},
  author={Jason H. Y. Wu and Amanda H. Lewis and J{\"o}rg Grandl},
  journal={Trends in biochemical sciences},
  volume={42 1},
In 2010, two proteins, Piezo1 and Piezo2, were identified as the long-sought molecular carriers of an excitatory mechanically activated current found in many cells. This discovery has opened the floodgates for studying a vast number of mechanotransduction processes. Over the past 6 years, groundbreaking research has identified Piezos as ion channels that sense light touch, proprioception, and vascular blood flow, ruled out roles for Piezos in several other mechanotransduction processes, and… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 29 extracted citations


Publications referenced by this paper.
Showing 1-10 of 86 references

Piezo proteins are pore-forming subunits of mechanically activated channels

  • B Coste
  • Nature
  • 2012
Highly Influential
5 Excerpts

A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons

  • D Florez-Paz
  • Sci. Rep
  • 2016
1 Excerpt

Similar Papers

Loading similar papers…