Totally drug‐resistant tuberculosis and adjunct therapies

@article{Parida2015TotallyDT,
  title={Totally drug‐resistant tuberculosis and adjunct therapies},
  author={Shreemanta K. Parida and Rebecca Axelsson-Robertson and Malavika Rao and N Singh and Iqbal Master and Anton A Lutckii and Salmaan Keshavjee and Jan Andersson and Alimuddin Zumla and Markus Maeurer},
  journal={Journal of Internal Medicine},
  year={2015},
  volume={277},
  pages={388 - 405}
}
The first cases of totally drug‐resistant (TDR) tuberculosis (TB) were reported in Italy 10 years ago; more recently, cases have also been reported in Iran, India and South Africa. Although there is no consensus on terminology, it is most commonly described as ‘resistance to all first‐ and second‐line drugs used to treat TB’. Mycobacterium tuberculosis (M.tb) acquires drug resistance mutations in a sequential fashion under suboptimal drug pressure due to monotherapy, inadequate dosing… 

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