• Corpus ID: 94691290

Total synthesis of the proposed structure of sclerophytin F and structure re-evaluation

@inproceedings{Delion2014TotalSO,
  title={Total synthesis of the proposed structure of sclerophytin F and structure re-evaluation},
  author={La{\"e}titia Delion},
  year={2014}
}
The thesis presents the first enantioselective synthesis of the proposed structure of sclerophytin F and consequently, the first total synthesis of a cladiellin family member having the S-configuration at the C-3 stereocentre. Three novel enantioselective routes are described to access a pivotal intermediate; then, the synthesis follows three key steps: i) radical-mediated cyclisation, ii) oxonium ylide formation and [2,3]-sigmatropic rearrangement, iii) Diels-Alder cycloaddition to deliver the…