Total synthesis of the marine alkaloid Mansouramycin D.

@article{Prakash2014TotalSO,
  title={Total synthesis of the marine alkaloid Mansouramycin D.},
  author={K. Prakash and R. Nagarajan},
  journal={Organic letters},
  year={2014},
  volume={16 1},
  pages={
          244-6
        }
}
Mansouramycin D, a cytotoxic alkaloid was isolated from a marine Streptomyces sp. in 2009. The first, simple, and concise route to the total synthesis of Mansouramycin D is reported. The core structure of the isoquinoline ring has been constructed from iminoannulation of 2-alkynylbenzaldehyde followed by oxidation/deprotection and oxidative amination via a three-step sequence from easily accessible starting materials. 
Synthesis, cytotoxicity and pro-apoptosis activity of isoquinoline quinones
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