Total synthesis of taxol

@article{Nicolaou1994TotalSO,
  title={Total synthesis of taxol},
  author={K. Nicolaou and Z. Yang and J. J. Liu and H. Ueno and P. Nantermet and R. Guy and C. Claiborne and J. Renaud and E. Couladouros and K. Paulvannan and E. J. Sorensen},
  journal={Nature},
  year={1994},
  volume={367},
  pages={630-634}
}
TAXOL1–4, a substance originally isolated from the Pacific yew tree (Taxus brevifolia) more than two decades ago, has recently been approved for the clinical treatment of cancer patients. Hailed as having provided one of the most significant advances in cancer therapy5, this molecule exerts its anticancer activity by inhibiting mitosis through enhancement of the polymerization of tubulin and consequent stabilization of microtubules6. The scarcity of taxol and the ecological impact of harvesting… Expand
Taxol: biosynthesis, molecular genetics, and biotechnological applications
The chemistry of taxol and related taxoids.
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Natural Sources of Taxol
Camptothecin and taxol: from discovery to clinic.
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Taxol, a molecule for all seasons
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