Total synthesis of salinosporamide A.

  title={Total synthesis of salinosporamide A.},
  author={Atsushi Endo and Samuel J Danishefsky},
  journal={Journal of the American Chemical Society},
  volume={127 23},
Total synthesis of potent proteasome inhibitor salinosporamide A (1) has been accomplished, which features strictly substrate-controlled operations starting with the only chiral center of (R)-pyroglutamic acid. The consecutive quaternary carbons within 1 have been efficiently constructed by manipulation of two intramolecular reactions: (1) carbonate-mediated internal acylation of imidate ester (4 --> 14) and (2) selenocyclization of aldehyde to exocyclic methylene group (5 --> 18).