Total synthesis of phorboxazole A via de novo oxazole formation: strategy and component assembly.

@article{Wang2011TotalSO,
  title={Total synthesis of phorboxazole A via de novo oxazole formation: strategy and component assembly.},
  author={B. Wang and T. M. Hansen and T. Wang and Dimao Wu and Lynn Weyer and Lu Ying and Mary M. Engler and Melissa Sanville and C. Leitheiser and M. Christmann and Yingtao Lu and Jiehao Chen and Nicholas Zunker and Russell D. Cink and F. Ahmed and Chi-Sing Lee and C. Forsyth},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 5},
  pages={
          1484-505
        }
}
The phorboxazole natural products are among the most potent inhibitors of cancer cell division, but they are essentially unavailable from natural sources at present. Laboratory syntheses based upon tri-component fragment coupling strategies have been developed that provide phorboxazole A and analogues in a reliable manner and with unprecedented efficiency. This has been orchestrated to occur via the sequential or simultaneous formation of both of the natural product's oxazole moieties from two… Expand
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