Total synthesis of nucleobase-modified adenophostin A mimics.

@article{Shuto2001TotalSO,
  title={Total synthesis of nucleobase-modified adenophostin A mimics.},
  author={S. Shuto and G. Horne and R. D. Marwood and B. Potter},
  journal={Chemistry},
  year={2001},
  volume={7 22},
  pages={
          4937-46
        }
}
  • S. Shuto, G. Horne, +1 author B. Potter
  • Published 2001
  • Chemistry, Medicine
  • Chemistry
  • The adenophostins exhibit approximately 10-100 times higher receptor binding and Ca2+ mobilising potencies in comparison with the natural second messenger D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3]. Despite many synthetic attempts to determine the minimal structural requirement for this unusual behaviour of the adenophostins, few related simplified analogues displaying higher activity than that of Ins(1,4,5)P3 have been reported. However, biological evaluation of such analogues has… CONTINUE READING
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