Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation.

Abstract

We have established an efficient synthetic methodology for the 13-oxyingenol natural derivative (13-oxyingenol-13-dodecanoate-20-hexanoate), featuring a ring-closing olefin metathesis reaction for the "direct" construction of a highly strained inside-outside framework and a Mislow-Evans-type [2,3]-sigmatropic rearrangement for the stereoselective… (More)

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@article{Ohyoshi2016TotalSO, title={Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation.}, author={Takayuki Ohyoshi and Yuki Tamura and Ichiro Hayakawa and Go Hirai and Yamato Miyazawa and Shota Funakubo and Mikiko Sodeoka and Hideo Kigoshi}, journal={Organic & biomolecular chemistry}, year={2016}, volume={14 48}, pages={11426-11437} }