Total synthesis of haterumalides NA and NC via a chromium-mediated macrocyclization.

@article{Schomaker2008TotalSO,
  title={Total synthesis of haterumalides NA and NC via a chromium-mediated macrocyclization.},
  author={Jennifer M Schomaker and Babak Borhan},
  journal={Journal of the American Chemical Society},
  year={2008},
  volume={130 37},
  pages={12228-9}
}
The syntheses of haterumalides NA and NC were accomplished via the macrocyclization of a chlorovinylidene chromium carbenoid onto a pendant aldehyde to generate the C8-C9 bond with the desired stereoisomer as the major product. Utilizing the latter chemistry enables access to both C9 hydroxylated (haterumalides NC and ND) and C9 deoxygenated forms… CONTINUE READING