Total synthesis of halipeptins: isolation of halipeptin D and synthesis of oxazoline halipeptin analogues.

@article{Nicolaou2005TotalSO,
  title={Total synthesis of halipeptins: isolation of halipeptin D and synthesis of oxazoline halipeptin analogues.},
  author={K. Nicolaou and Daniel Schlawe and David W. Kim and Deborah A. Longbottom and Rita G de Noronha and D. Lizos and R. Manam and D. Faulkner},
  journal={Chemistry},
  year={2005},
  volume={11 21},
  pages={
          6197-211
        }
}
The isolation from the marine sponge Leiosella cf. arenifibrosa and structural elucidation of halipeptin D (5), a relative of the previously isolated halipeptins A-C (1-3), is described along with the total synthesis of a number of oxazoline analogues (7 a-d and epi-7 c-d). The developed synthetic strategy provides a flexible entry into the various isomers of the polyketide domain of the halipeptins and improvises for a late stage construction of the oxazoline ring after a macrolactamization… Expand
21 Citations

Topics from this paper

Marine Depsipeptides as Promising Pharmacotherapeutic Agents.
Total synthesis of antimicrobial and antitumor cyclic depsipeptides.
...
1
2
3
...

References

SHOWING 1-10 OF 21 REFERENCES
Synthetic studies on bacitracin. VII. Isomerization of amino acid components of thiazoline peptides.
...
1
2
3
...