Total synthesis of ecteinascidin 743.

@article{Endo2002TotalSO,
  title={Total synthesis of ecteinascidin 743.},
  author={Atsushi Endo and Arata Yanagisawa and Masanao Abe and Shigemitsu Tohma and Toshiyuki Kan and Tohru Fukuyama},
  journal={Journal of the American Chemical Society},
  year={2002},
  volume={124 23},
  pages={
          6552-4
        }
}
The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol-aldehyde cyclization, and acid-induced intramolecular sulfide formation. 
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