Total synthesis of ecteinascidin 743.

  title={Total synthesis of ecteinascidin 743.},
  author={Atsushi Endo and Arata Yanagisawa and Masanao Abe and Shigemitsu Tohma and Toshiyuki Kan and Tohru Fukuyama},
  journal={Journal of the American Chemical Society},
  volume={124 23},
The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol-aldehyde cyclization, and acid-induced intramolecular sulfide formation. 
One-Pot Ugi/Aza-Michael Synthesis of Highly Substituted 2,5-Diketopiperazines with Anti-Proliferative Properties
The obtained diketopiperazines show anti-proliferative effects on activated T cells and represent therefore potential candidates for targeting unwanted T cell-mediated immune responses. Expand
Application of the Asymmetric Pictet–Spengler Reaction in the Total Synthesis of Natural Products and Relevant Biologically Active Compounds
This review aims to highlight the applications of the asymmetric variant of this old name reaction in the total synthesis of natural products, chiefly, alkaloids, which exhibit significant biological properties. Expand
Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development
The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Expand
Identification of novel deoxyribofuranosyl indole antimicrobial agents
Three novel deoxyribofuranosyl indole derivatives, FG050227 (1), FG050223 (2) and FG050204 (3), were identified as antimicrobial agents effective against Gram-positive bacterial strains and someExpand
Characterization of SafC, a Catechol 4-O-Methyltransferase Involved in Saframycin Biosynthesis
Results indicate that SafC-catalyzed 4′-O- methylation of l-dopa occurs prior to 5′-C-methylation, suggesting that 4′'-O-methylations is likely the first committed step in the biosynthesis of saframycin MX1. Expand
Cutting-Edge and Time-Honored Strategies for Stereoselective Construction of C-N Bonds in Total Synthesis.
This review provides a comprehensive survey of methods used for stereoselective construction of carbon-nitrogen bonds during the total synthesis of nitrogen-containing natural products that have appeared in the literature since 2000. Expand
Synthesis, Molecular Docking and Antimicrobial Activities of 3-Formyl-2- (1H)quinolinone Schiff Base Derivatives and 3-(((3-Acetylphenyl)imino)- methyl)quinolin-2-(1H)-one Chalcone Derivatives
Some of Schiff base derivatives were separated by condensing 3-formyl-2-quinolinone with various primary amine derivatives in ethanol, in which water is expelled. Moreover, substitutedExpand
Practical Synthesis of 1-(7-Fluoro-naphthalen-1-yl)piperazine Hydrochloride
Abstract A practical and scalable preparation of 1-(7-fluoronaphthalen-1-yl)-piperazine hydrochloride (1) is reported. The original route for the synthesis of this compound involved the use ofExpand
Asymmetric phosphoric acid–catalyzed four-component Ugi reaction
It is shown that chiral phosphoric acids can catalyze the four-component coupling with high enantioselectivity and be targeted as a catalyst for asymmetric Ugi-4CR, well suited for diversity-oriented synthesis applicable in drug discovery. Expand
Organo Catalysed Microwave Assisted Three Component Reaction to Produce 1, 5- Benzodiazepine Derivatives
A microwave assisted solventless one pot three component reaction of 1, 2 phenylenediamine, aromatic aldehydes  and s-keto esters in presence of catalytic amount of tirchloroacetic acid to produce 1,Expand