Total synthesis of dispyrin, purpurealidin E, and aplysamine-1.

@article{Yoshida2008TotalSO,
  title={Total synthesis of dispyrin, purpurealidin E, and aplysamine-1.},
  author={Makoto Yoshida and Kentaro Yamaguchi},
  journal={Chemical & pharmaceutical bulletin},
  year={2008},
  volume={56 9},
  pages={1362-3}
}
Bromotyrosine alkaloids dispyrin (1), purpurealidin E (2), and aplysamine-1 (3) isolated from marine sponge, were synthesized from commercially available tyramine (4) as a common starting material. The overall yield was 18%, 39%, and 22% for 1 from 4 in 5 steps, 2 in 5 steps, and 3 in 6 steps, respectively.