Total synthesis of a tetracyclic anti-tumor, UCE6.

@article{Tatsuta2002TotalSO,
  title={Total synthesis of a tetracyclic anti-tumor, UCE6.},
  author={Kuniaki Tatsuta and Takayuki Inukai and Sayaka Itoh and Masataka Kawarasaki and Yuko Nakano},
  journal={The Journal of antibiotics},
  year={2002},
  volume={55 12},
  pages={
          1076-80
        }
}
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Total synthesis and development of bioactive natural products
  • K. Tatsuta
  • Chemistry, Medicine
  • Proceedings of the Japan Academy. Series B, Physical and biological sciences
  • 2008
TLDR
The first total synthesis and development of a variety of bioactive natural products have been accomplished by using carbohydrates as a chiral source by using the “Big Four” antibiotics and a side-chain of cephem antibiotics. Expand

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The first total syntheses of a variety of useful bioactive compounds have been accomplished by practically useful strategies. In addition practically useful intermediates have been developed,Expand
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Most of these protocols rely on highly toxic selenium reagents in oneor two-step procedures. 2 Another regularly employed tactic involves palladium-catalyzed oxidation of the enol-ethers derived fromExpand
UCE6, a new antitumor antibiotic with topoisomerase I-mediated DNA cleavage activity produced by actinomycetes: producing organism, fermentation, isolation and biological activity.
TLDR
UCE6 exhibited growth inhibitory activity against HeLa S3, HCT116 and Lu-65 cells comparable to that of camptothecin and addition of silicone oil antifoam agent, KS69, to the fermentation enhanced the production of UCE6 by approximately 3 fold. Expand
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Abstract Enol diisopinocampheylborinates, derived from achiral ethyl and methyl ketones by enolisation in the presence of tertiary amine bases (iPr2NEt or Et3N), undergo enantio- andExpand
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Under stannic chloride catalysis, 2-carbomethoxy-2-cyclohexen-1-one (5) was found to undergo Diels–Alder reaction with a variety of dienes to give directly the cis-1-octalone system possessing aExpand