Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.

  title={Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.},
  author={Nolan R. Mente and A. Wiemer and J. D. Neighbors and J. Beutler and R. Hohl and D. Wiemer},
  journal={Bioorganic & medicinal chemistry letters},
  volume={17 4},
  • Nolan R. Mente, A. Wiemer, +3 authors D. Wiemer
  • Published 2007
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • Total synthesis of the (R,R,R)- and (S,S,S)-enantiomers of the natural product schweinfurthin F has been completed. Comparisons of spectral data and optical rotations with those reported for the natural product, as well as a variety of bioassay data, allow assignment of the natural material as the (R,R,R)-isomer. 
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