Total synthesis of (-)-mucocin.


[reaction: see text] An enantioselective total synthesis of (-)-mucocin has been completed. A combination of asymmetric glycolate aldol additions and ring closing metathesis reactions were exploited to construct the C18-C34 and C7-C17 fragments. A selective cross-metathesis reaction was employed as the key step to couple two complex fragments. 


Cite this paper

@article{Crimmins2006TotalSO, title={Total synthesis of (-)-mucocin.}, author={Michael T Crimmins and Yan Zhang and Frank Diaz}, journal={Organic letters}, year={2006}, volume={8 11}, pages={2369-72} }