Total synthesis of (-)-lepenine.

@article{Nishiyama2014TotalSO,
  title={Total synthesis of (-)-lepenine.},
  author={Yoshitake Nishiyama and Yuki Han-ya and Satoshi Yokoshima and Tohru Fukuyama},
  journal={Journal of the American Chemical Society},
  year={2014},
  volume={136 18},
  pages={
          6598-601
        }
}
The first asymmetric total synthesis of lepenine has been accomplished. The synthesis features a tethered intramolecular Diels-Alder reaction, an intramolecular Mannich reaction, and a Diels-Alder reaction between an ortho-quinone monoketal and ethylene, resulting in stereoselective construction of the unique hexacyclic system. 

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