Total synthesis of (+)-phorboxazole A.

@article{Smith2001TotalSO,
  title={Total synthesis of (+)-phorboxazole A.},
  author={A. Smith and P. Verhoest and K. Minbiole and M. Schelhaas},
  journal={Journal of the American Chemical Society},
  year={2001},
  volume={123 20},
  pages={
          4834-6
        }
}
A highly convergent, stereocontrolled total synthesis of the potent antiproliferative agent ( +)phorboxazole A ( 1) has been achieved. Highlights of the synthesis include: modified Petasis -Ferrier rearrangements for assembly of both the C(11 5) and C(22-26) cis-tetrahydropyran rings; extension of the Julia olefination to the synthesis of enol ethers; the design, synthesis, and application of a novel bifunctional oxazole linchpin; and Stille coupling of a C(28) trimethyl stannane with a C(29… Expand
Studies of stereocontrolled allylation reactions for the total synthesis of phorboxazole A.
Total synthesis of phorboxazole B.
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References

Scheme 28 Scheme 29 Scheme 30