Total synthesis of (+)-kalkitoxin.

@article{White2003TotalSO,
  title={Total synthesis of (+)-kalkitoxin.},
  author={James A. White and Chang-Sun Lee and Qing Xu},
  journal={Chemical communications},
  year={2003},
  volume={16},
  pages={2012-3}
}
The neurotoxic lipopeptide (+)-kalkitoxin was synthesized by a route which employed asymmetric organocopper conjugate addition followed by in situ enolate alkylation to install the anti,anti-1,2,4-trimethyl relationship of the toxin; the synthesis of kalkitoxin required sixteen steps and proceeded in 3% overall yield.