Total synthesis of (+/-)-perophoramidine.

@article{Fuchs2004TotalSO,
  title={Total synthesis of (+/-)-perophoramidine.},
  author={James R Fuchs and Raymond L. Funk},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 16},
  pages={5068-9}
}
The first total synthesis of racemic perophoramidine is described. The key step features the highly stereoselective introduction of the vicinial quaternary centers via base-promoted carbon-carbon bond formation between a 3-alkylindole and a 3-bromo-3-alkylindolin-2-one. This transformation presumably proceeds through a conjugate addition or Diels-Alder… CONTINUE READING