Total synthesis and study of 6-deoxyerythronolide B by late-stage C-H oxidation.

@article{Stang2009TotalSA,
  title={Total synthesis and study of 6-deoxyerythronolide B by late-stage C-H oxidation.},
  author={Erik M Stang and M Christina White},
  journal={Nature chemistry},
  year={2009},
  volume={1 7},
  pages={547-51}
}
Among the frontier challenges in chemistry in the twenty-first century are the interconnected goals of increasing synthetic efficiency and diversity in the construction of complex molecules. Oxidation reactions of C-H bonds, particularly when applied at late stages of complex molecule syntheses, hold special promise for achieving both these goals. Here we report a late-stage C-H oxidation strategy in the total synthesis of 6-deoxyerythronolide B (6-dEB), the aglycone precursor to the… CONTINUE READING