Total synthesis and structure confirmation of leptofuranin D.

Abstract

A convergent total synthesis of leptofuranin D is described. The linear polyketide C12-C24 segment was assembled through addition of a chiral allenylzinc reagent, derived from mesylate 12, to the chiral aldehyde 11. Directed hydrostannation of the adduct 13 followed by iodinolysis and Sonogashira coupling yielded the enyne 16, which was converted to the… (More)

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Cite this paper

@article{Marshall2003TotalSA, title={Total synthesis and structure confirmation of leptofuranin D.}, author={James A.R. Marshall and Gregory M Schaaf}, journal={The Journal of organic chemistry}, year={2003}, volume={68 19}, pages={7428-32} }