Total synthesis and structural revision of vannusals A and B: synthesis of the originally assigned structure of vannusal B.

@article{Nicolaou2010TotalSA,
  title={Total synthesis and structural revision of vannusals A and B: synthesis of the originally assigned structure of vannusal B.},
  author={K C Nicolaou and Adrian Ortiz and Hongjun Zhang and Philippe Dagneau and Andreas Lanver and Michael P Jennings and Stellios Arseniyadis and Raffaella Faraoni and Dimitrios E Lizos},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 20},
  pages={7138-52}
}
The total synthesis of the originally assigned structure of vannusal B (2) and its diastereomer (d-2) are described. Initial forays into these structures with model systems revealed the viability of a metathesis-based approach and a SmI(2)-mediated strategy for the key cyclization to forge the central region of the molecule, ring C. The former approach was… CONTINUE READING