Total synthesis and structural confirmation of ent-galbanic acid and marneral.

  title={Total synthesis and structural confirmation of ent-galbanic acid and marneral.},
  author={Andrei Corbu and Manuel Ivan Giron Perez and Maurizio Aquino and Pascal Retailleau and Sim{\'e}on Arseniyadis},
  journal={Organic letters},
  volume={10 13},
By capitalizing on a highly selective Claisen rearrangement, ent-galbanic acid 1 and (+)-marneral 2 have been synthesized. The relative configurations of (+)- 1 and (+)- 2 were unambiguously established by X-ray crystallographic analysis of the precursors 11a and 20, with the absolute configuration ensuing from their derivation from R-pulegone. In this way, the controversial issue of the configuration of galbanic acid was unequivocally settled. 

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