Total synthesis and neuroprotective effect of O-methylmurrayamine A and 7-methoxymurrayacine

@article{Zang2017TotalSA,
  title={Total synthesis and neuroprotective effect of O-methylmurrayamine A and 7-methoxymurrayacine},
  author={Yingda Zang and Chuang-jun Li and Xiu-yun Song and Jie Ma and Jing-zhi Yang and Nai-hong Chen and Dong‐ming Zhang},
  journal={Journal of Asian Natural Products Research},
  year={2017},
  volume={19},
  pages={623 - 629}
}
Abstract O-Methylmurrayamine A (7) and 7-methoxymurrayacine (8) are natural products isolated from Murraya koenigii and Murraya siamensis, respectively. In this paper, we report the synthesis of 7 and 8 which are featured in the key step of cyclization to form carbazole intermediate 5 with mild conditions. The structures were confirmed by 1H NMR, 13C NMR, and HR-ESI-MS. In addition, compounds 7 and 8 were tested for their neuroprotective effects against H2O2-induced PC12 cell damage. The… 
Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and Its Primary Bioactive Compounds
TLDR
The present review provides insight into the major components of Murraya koenigii and their pharmacological activities against different pathological conditions and emphasizes the need for more research on the molecular basis of such activity in various cellular and animal models to validate the efficacy of M. koenigsii and its derivatives as potent therapeutic agents.

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