Total synthesis and neuroprotective effect of O-methylmurrayamine A and 7-methoxymurrayacine

  title={Total synthesis and neuroprotective effect of O-methylmurrayamine A and 7-methoxymurrayacine},
  author={Yingda Zang and Chuang-jun Li and Xiu-yun Song and Jie Ma and Jing-zhi Yang and Nai-hong Chen and Dong‐ming Zhang},
  journal={Journal of Asian Natural Products Research},
  pages={623 - 629}
Abstract O-Methylmurrayamine A (7) and 7-methoxymurrayacine (8) are natural products isolated from Murraya koenigii and Murraya siamensis, respectively. In this paper, we report the synthesis of 7 and 8 which are featured in the key step of cyclization to form carbazole intermediate 5 with mild conditions. The structures were confirmed by 1H NMR, 13C NMR, and HR-ESI-MS. In addition, compounds 7 and 8 were tested for their neuroprotective effects against H2O2-induced PC12 cell damage. The… 
Medicinal Profile, Phytochemistry, and Pharmacological Activities of Murraya koenigii and Its Primary Bioactive Compounds
The present review provides insight into the major components of Murraya koenigii and their pharmacological activities against different pathological conditions and emphasizes the need for more research on the molecular basis of such activity in various cellular and animal models to validate the efficacy of M. koenigsii and its derivatives as potent therapeutic agents.


Comparison of antioxidative properties of carbazole alkaloids from Murraya koenigii leaves.
A new dimeric carbazole alkaloid, 8,10‘-[3,3‘,11,11‘-tetrahydro-9,9‘-dihydroxy-3,3‘,5,8‘-tetramethyl-3,3‘-bis(4-methyl-3-pentenyl)]bipyrano[3,2-a]carbazole (12), was isolated from the CH2Cl2 extract
Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents.
Koenidine (4) was identified as a metabolically stable antidiabetic compound, when evaluated in a rodent type 2 model, and showed a considerable reduction in the postprandial blood glucose profile with an improvement in insulin sensitivity.
Synthesis of prenyl- and geranyl-substituted carbazole alkaloids by DIBAL-H promoted reductive pyran ring opening of dialkylpyrano[3,2-a]carbazoles.
In the course of the present work, the DIBAL-H promoted reductive pyran ring opening of dialkylpyrano[3,2-a]carbazoles provides a direct access to a broad range of prenyl- and geranyl-substituted carbazoles.
Palladium(II)-catalysed total synthesis of naturally occurring pyrano[3,2-a]carbazole and pyrano[2,3-b]carbazole alkaloids.
Seven naturally occurring pyranocarbazole alkaloids have been obtained by total synthesis using a palladium(II)-catalysed oxidative cyclisation of a diarylamine to an orthogonally diprotected 2,7-dihydroxycarbazole as key step.
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