Total synthesis and conformational analysis of apratoxin C.

  title={Total synthesis and conformational analysis of apratoxin C.},
  author={Y. Masuda and J. Suzuki and Y. Onda and Yuta Fujino and M. Yoshida and T. Doi},
  journal={The Journal of organic chemistry},
  volume={79 17},
  • Y. Masuda, J. Suzuki, +3 authors T. Doi
  • Published 2014
  • Chemistry, Medicine
  • The Journal of organic chemistry
  • Total synthesis of apratoxin C, a cyanobacterial cyclodepsipeptide with highly potent cytotoxicity against some cancer cell lines, was achieved using the apratoxin A synthetic strategy developed by us. To elucidate the relationship between conformation and activity, the tertiary structure of apratoxin C was analyzed by NMR spectroscopy. We obtained 37 ROEs and five (3)JH,H values, which were translated into distance and dihedral angle constraints, respectively. Molecular modeling was performed… CONTINUE READING
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