Total synthesis and biological evaluation of fluorinated cryptophycins

  title={Total synthesis and biological evaluation of fluorinated cryptophycins},
  author={Christine Weiss and Tobias Bogner and Benedikt Sammet and Norbert Sewald},
  booktitle={Beilstein journal of organic chemistry},
Cryptophycins are cytotoxic natural products that exhibit considerable activities even against multi-drug-resistant tumor cell lines. As fluorinated pharmaceuticals have become more and more important during the past decades, fluorine-functionalized cryptophycins were synthesized and evaluated in cell-based cytotoxicity assays. The unit A trifluoromethyl-modified cryptophycin proved to be highly active against KB-3-1 cells and exhibited an IC(50) value in the low picomolar range. However, the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.


Publications referenced by this paper.
Showing 1-3 of 3 references

University of Hawaii, Wayne State University), Cryptophycins From Aberrant Biosynthesis

R. E. Moore, T. K. Hemscheidt
WO9708334A1, March • 1997
View 5 Excerpts
Highly Influenced

Synthese von Cryptophycin-Analoga für SAR- und subzelluläre Lokalisationsstudien

C. Weiß
Ph.D. Thesis, • 2012
View 1 Excerpt

Synthese von Cryptophycinen für SAR-Studien

S. Eißler
Ph.D. Thesis, • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…