Total synthesis and biological evaluation of (-)-apicularen A and its analogues.

@article{Palimkar2012TotalSA,
  title={Total synthesis and biological evaluation of (-)-apicularen A and its analogues.},
  author={Sanjay S Palimkar and Jun'ichi Uenishi and Hiromi},
  journal={The Journal of organic chemistry},
  year={2012},
  volume={77 1},
  pages={388-99}
}
The total synthesis of (-)-apicularen A (1), a highly cytostatic 12-membered macrolide, and its analogues is described. The convergent and distinct approach not only provides 1, but also opens the opportunity to synthesize C10-C11 functional analogues of 1. The key steps of the total synthesis include assembling of iodoalkene 12 and aldehyde 13by Nozaki… CONTINUE READING