Total synthesis and bioactivity of 18(R)-hydroxyeicosapentaenoic acid.

@article{Krishnamurthy2011TotalSA,
  title={Total synthesis and bioactivity of 18(R)-hydroxyeicosapentaenoic acid.},
  author={Venkata R Krishnamurthy and A. Dougherty and C. Haller and E. Chaikof},
  journal={The Journal of organic chemistry},
  year={2011},
  volume={76 13},
  pages={
          5433-7
        }
}
Resolvins are family of lipid mediators derived from omega-3 polyunsaturated fatty acids, which are generated during the resolution phase of acute inflammation. Resolvin E1 is biosynthesized from eicosapentaenoic acid via 18(R)-hydroxyeicosapentaenoic acid (18R-HEPE) in the Cox-2 and lipoxygenase mediated pathway and has proven to exhibit potent anti-inflammatory activity. We report herein the first total chemical synthesis of 18R-HEPE and demonstrate that this compound displays in vivo… Expand
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