Total synthesis and anticancer activity of highly potent novel glycolipid derivatives.

Abstract

The total synthesis and anticancer activity of several novel derivatives based on a dauer effect-inducing glycolipid are presented. A versatile and convergent synthesis was accomplished through stereospecific alpha-glycosylation, which produced di- and tri-rhamnoside daumone derivatives. Most of the synthetic derivatives possessed potent anticancer activity… (More)
DOI: 10.1016/j.ejmech.2009.03.007

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