Total synthesis and absolute stereochemistry of the proteasome inhibitors cystargolides A and B.

@article{TelloAburto2015TotalSA,
  title={Total synthesis and absolute stereochemistry of the proteasome inhibitors cystargolides A and B.},
  author={Rodolfo Tello-Aburto and Liam P. Hallada and Doleshwar Niroula and Snezna Rogelj},
  journal={Organic \& biomolecular chemistry},
  year={2015},
  volume={13 40},
  pages={
          10127-30
        }
}
The absolute stereochemistry of the cystargolides was determined by total synthesis. Evaluation of synthetic cystargolides and derivatives showed that the natural (2S,3R) stereochemistry is essential for activity. Moreover, benzyl esters (-)-10 and (-)-15 were found to be about 100 times more potent, and to selectively kill MCF-7 cancerous cells. 
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7 Citations

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The following review discusses the efforts made in the field to isolate and identify natural products as inhibitors of the proteasome and some of the modifications made to natural products in order to discover more potent and selective inhibitors for potential disease treatment.
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Evaluation of the bioactivity of the natural products expressed by the most prevalent cluster families explains the functional basis of bacterial natural products involved in bacteria–nematode–insect interactions.

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