Total syntheses of tumor-related antigens N3: probing the feasibility limits of the glycal assembly method.

  title={Total syntheses of tumor-related antigens N3: probing the feasibility limits of the glycal assembly method.},
  author={H. M. Kim and I. J. Kim and Samuel J Danishefsky},
  journal={Journal of the American Chemical Society},
  volume={123 1},
The total syntheses of two octasaccharide antigens isolated from human milk, 1 and 2, and their corresponding allyl glycosides, 3 and 4, have been achieved by utilizing the glycal method. Convergent assembly of the core hexasaccharides and concurrent introduction of two alpha-L-fucosyl moieties at the late stage of the syntheses provided these complex carbohydrates in a concise manner. With synthetic material obtained, biological evaluations of these antigens as potential gastrointestinal… 
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