Total syntheses of the telomerase inhibitors dictyodendrin B, C, and E.

  title={Total syntheses of the telomerase inhibitors dictyodendrin B, C, and E.},
  author={Alois F{\"u}rstner and Mathias M. Domostoj and Bodo Scheiper},
  journal={Journal of the American Chemical Society},
  volume={128 24},
Concise and flexible total syntheses of the pyrrolo[2,3-c]carbazole alkaloids dictyodendrin B (2), C (3), and E (5) are described. These polycyclic telomerase inhibitors of marine origin derive from the common intermediate 18 which was prepared on a multigram scale by a sequence comprising a TosMIC cycloaddition with formation of the pyrrole A-ring, a titanium-induced reductive oxoamide coupling reaction to generate an adjacent indole nucleus, and a photochemical 6pi-electrocyclization… 
Total synthesis of dictyodendrin A and B.
The first total synthesis of dictyodendrins A and B is reported which features a hitherto unprecedented benzyne-mediated one-pot cyclization/cross-coupling sequence.
Total syntheses of the tylophora alkaloids cryptopleurine, (-)-antofine, (-)-tylophorine, and (-)-ficuseptine C.
A concise, efficient and modular approach to the tylophora alkaloids is described, a family of potent cytotoxic agents that are equally effective against drug sensitive and multidrug resistant cancer
Total syntheses of the actin-binding macrolides latrunculin A, B, C, M, S and 16-epi-latrunculin B.
A previously unknown acid-catalyzed degradation pathway of these bioactive natural products is described, with cysteine-derived ketone 18, the tetrahydropyranyl segment 31 serving as the common synthesis platform for the preparation of all naturally occurring latrunculins.
Total synthesis, molecular editing and evaluation of a tripyrrolic natural product: the case of "butylcycloheptylprodigiosin".
This dispute has been resolved by an unambiguous total synthesis of this complex alkaloid which confirms the initial structure assignment and results in complete loss of the very pronounced ability of the parent compound 6 to induce oxidative cleavage in double stranded DNA in the presence of Cu(II).
Synthetic Approach to Telomerase Inhibitor Dictyodendrin B: Synthesis of the Pyrrolo[2,3-c]carbazole Core
The core structure of the telomerase inhibitor, dictyodendrin B, was synthesized by using the palladium-catalyzed cross-coupling reaction of
Molecular editing and biological evaluation of amphidinolide X and Y.
The resulting products provided first insights into the cytotoxicity profile of these extremely scarce macrolides, and it was found that certain bladder, colon and prostate cancer cell lines are fairly sensitive, and that the best synthetic analogues are more active than the natural products themselves.
Modular synthesis of lamellarins via regioselective assembly of 3,4,5-differentially arylated pyrrole-2-carboxylates.
A modular synthesis of lamellarins via 3,4,5-differentially arylated pyrrole-2-carboxylate intermediates using readily accessible arylboronic acids as aromatic modules allows the production of diverse lameLLarins in short steps with high yields.
Total Synthesis of Dictyodendrins A-F by the Gold-Catalyzed Cascade Cyclization of Conjugated Diyne with Pyrrole.
The total synthesis of dictyodendrins A-F was achieved using the gold(I)-catalyzed annulation of a conjugated diyne with N-Boc-pyrrole for direct construction of the pyrrolo[2,3-c]carbazole scaffold.