Total syntheses of isonaamine C and isonaamidine E.

  title={Total syntheses of isonaamine C and isonaamidine E.},
  author={H. Lima and Beatriz Garcia-Barboza and Nicole N Khatibi and C. J. Lovely},
  journal={Tetrahedron letters},
  volume={52 44},
The total syntheses of two alkaloids isolated from a marine sponge of the Leucetta sp. have been accomplished in 6 and 7 steps starting from a 4,5-diiodoimidazole derivative. Grignard mediated halogen-metal exchange was used to install the benzyl side chain. C2 substitution was accomplished via lithiation followed by quenching with trisyl azide which provided isonaamine C after hydrogenation. Isonaamidine E was then prepared from isonaamine C via introduction of the hydantoin ring by reaction… Expand
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