Total syntheses of (-)-hanishin, (-)-longamide B, and (-)-longamide B methyl ester via a novel preparation of N-substituted pyrrole-2-carboxylates [corrected].

Abstract

A novel preparation of N-substituted pyrrole-2-carboxylates has been developed based upon 1,3-dipolar cycloaddition and a conventional hydrogenolysis. By using this method as the key step, total syntheses of natural alkaloids (-)-hanishin, (-)-longamide [corrected] B, and (-)-longamide [corrected] B methyl ester were accomplished in the highest overall yields, respectively.

DOI: 10.1021/ol203433c

Cite this paper

@article{Cheng2012TotalSO, title={Total syntheses of (-)-hanishin, (-)-longamide B, and (-)-longamide B methyl ester via a novel preparation of N-substituted pyrrole-2-carboxylates [corrected].}, author={Guolin Cheng and Xinyan Wang and Hailin Bao and Chuanjie Cheng and Nan Liu and Yuefei Hu}, journal={Organic letters}, year={2012}, volume={14 4}, pages={1062-5} }