Total syntheses and biological investigations of tamandarins A and B and tamandarin A analogs.

Abstract

Tamandarins A (1) and B (2), two natural products similar in structure to didemnin B (3), were recently isolated from a Brazilian marine ascidian of the family Didemnidae. The cytotoxicity of 1 was reported to be somewhat more potent in vitro than that of 3 against various human cancer cell lines. The present account describes the first total syntheses of 1 and 2, and the syntheses of tamandarin A side chain analogues. The cytotoxicity data for these compounds show that the side chain modifications exhibit a parallel effect for both didemnins and tamandarins. This observation supports tamandarins' role as didemnins' mimic.

Cite this paper

@article{Liang2001TotalSA, title={Total syntheses and biological investigations of tamandarins A and B and tamandarin A analogs.}, author={B L Liang and Daniel J. Richard and Padma Portonovo and Madeleine M. Joulli{\'e}}, journal={Journal of the American Chemical Society}, year={2001}, volume={123 19}, pages={4469-74} }