Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula.

@article{Luesch2001TotalSD,
  title={Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula.},
  author={H. Luesch and W. Yoshida and R. Moore and V. Paul and T. Corbett},
  journal={Journal of the American Chemical Society},
  year={2001},
  volume={123 23},
  pages={
          5418-23
        }
}
  • H. Luesch, W. Yoshida, +2 authors T. Corbett
  • Published 2001
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • Apratoxin A (1), a potent cytotoxin with a novel skeleton, has been isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont. This cyclodepsipeptide of mixed peptide-polyketide biogenesis bears a thiazoline ring flanked by polyketide portions, one of which possesses an unusual methylation pattern. Its gross structure has been elucidated by spectral analysis, including various 2D NMR techniques. The absolute configurations of the amino acid-derived units were determined by… CONTINUE READING
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